A postdoctoral position is available in the field of chemical oncology and transcriptional control of oncogenesis. The Durbin lab is interested in a broad, “multi-omics” approach to the epigenetically-coded processes that drive pediatric cancer. The primary research focus of the Durbin laboratory involves studying epigenetic determinants of gene regulation and transcriptional regulatory complexes in pediatric solid tumors to identify synergistic ways to target cancer cell growth. The Durbin laboratory uses combinations of functional genomics, chemical biology and epigenomics to identify and characterize these dominant transcriptional regulatory complexes, their co-activators and co-repressors to define mechanistically-based strategies for pediatric solid tumor therapy. The long-term goal of the Durbin laboratory is to deeply understand fundamental aspects of the epigenetic control of transcription in tumor cell biology, in order to advance therapeutic development.
The candidate should have expertise in tissue culture, western blotting/co-immunoprecipitation, molecular cloning, functional genomics techniques including CRISPR-cas9 gene editing, and shRNA and siRNA gene disruption. Prior experience with cancer biology, mouse or zebrafish xenografts, liquid handling robotics, high-throughput screening, confocal microscopy and computational biology is appreciated but not required. Experience with R is required.
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