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Post-Doctoral Fellow – Innovation Chemistry team
Alnylam in the Cambridge, Massachusetts
 
 
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Date Posted April 18, 2019
Category
Postdoctoral-Chemistry
Employment Type Full-time
Application Deadline Open until filled
 
 
 

Post-Doctoral Fellow – Innovation Chemistry team

Overview

Alnylam was founded in 2002 on a revolutionary vision and bold mission which remain firmly in place today. We are leading the translation of RNA interference (RNAi) into a new class of innovative medicines with the potential to transform the lives of people with rare genetic, cardio-metabolic, hepatic infectious, and central nervous system diseases with unmet need. Our first medicine, the first-ever RNAi therapeutic, has recently been approved by the FDA in the US for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults and by the European Medicines Agency in the EU for the treatment of hATTR amyloidosis in adults with stage 1 or stage 2 polyneuropathy. In addition, Alnylam has four investigational medicines in late-stage development. www.alnylam.com. Alnylam is proud to have been recognized as one of The Boston Globe’s Top Places to Work in 2015, 2016, 2017 and 2018- four years in a row!

Seeking an experienced organic/medicinal chemist/bioorganic chemist with expertise in design, synthesis, analysis of small molecules, nucleosides and oligonucleotides. The candidate should have expertise in scientific literature, database and patent search; modern analytical and separation techniques and instrumentation. Successful candidate will work in a multidisciplinary environment.

Summary of Key Responsibilities

  • Design and synthesis of small molecules, heterocycles, lipids, carbohydrates, nucleosides and nucleotides, oligonucleotides and conjugates; knowledge in design, synthesis, analysis of drug delivery systems and conjugates for nucleic acids.

  • Purification of compounds using modern separation techniques

  • Analysis and characterization using modern analytical techniques (NMR, MS, HPLC, IR, etc.).

  • Multitasking and multidisciplinary expertise

  • Expertise in scientific data base, literature survey and patent search

  • Manuscript Writing skills

Qualifications

  • PhD in Organic Chemistry or bioorganic chemistry

  • 0-5 years of post-doctoral experience

  • Hands on experience on separation and analytical instrumentation and scientific database search.

  • Instrumentation skills, desire to learn bioassays, oligonucleotide synthesis

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.

#LI-LM1

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